Chronic kidney disease symptoms progress slowly, so early signs are often mild or unnoticed. As kidney function weakens, people may experience constant tiredness, low energy, and reduced focus. Fluid buildup in the body can cause swelling in the feet, ankles, legs, hands, or around the eyes. Urinary changes such as frequent nighttime urination, decreased urine output, foamy urine, or blood in the urine may occur. Other common symptoms include nausea, vomiting, poor appetite, unintended weight loss, muscle cramps, dry and itchy skin, shortness of breath, sleep problems, and persistently high blood pressure, reflecting gradual kidney damage.